METHUSELAH ARCHIVE LINEAGE / BORROWED-VITALITY
Lineage

Borrowed vitality

A historical comparison of rejuvenation claims built around injected extracts, grafted glands, infused cells or serum, and exchanged plasma.
span:1889–present
cases:7
status:live terminus
terminus:Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG)
THE THREAD
1889–1894 Brown-Séquard testicular extract (organotherapy) brown-sequard-self-injection-1889 1893–1908 Spermin-Poehl (Sperminum-Poehl) organotherapy poehl-spermine-1893-1908 1897–1925 Marine plasma (Sérum de Quinton) quinton-marine-plasma-1897-1925 1920–1935 Voronoff testicular xenograft (chimpanzee-to-human) voronoff-graft-1920-1935 1931–1971 Cellular therapy (Frischzellentherapie) niehans-fetal-cells-1931-1971 1934–1950 Antireticular cytotoxic serum (ACS / ATsS) bogomolets-acs-1934-1950 2024–present Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG) LIVE TERMINUS tpe-ivig-2024-present
THROUGH-LINE

Historical members changed the material and route while retaining the proposal that acting on a biological substance could restore vitality. Any present member's operation and evidence status remain confined to that member's Case and sources.

The historical record repeatedly proposed restoring vitality by acting on a biological substance through injection, graft, or infusion. This page groups source-backed comparison edges for navigation. Any present member’s operation and evidence status are stated only in that member’s Case and attached sources; historical outcomes do not transfer.

CASES IN THIS LINEAGE
  1. Brown-Séquard testicular extract (organotherapy) (1889–1894)
  2. Spermin-Poehl (Sperminum-Poehl) organotherapy (1893–1908)
  3. Marine plasma (Sérum de Quinton) (1897–1925)
  4. Voronoff testicular xenograft (chimpanzee-to-human) (1920–1935)
  5. Cellular therapy (Frischzellentherapie) (1931–1971)
  6. Antireticular cytotoxic serum (ACS / ATsS) (1934–1950)
  7. Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG) (2024–present) · LIVE TERMINUS
EDGE EVIDENCE

Brown-Séquard testicular extract (organotherapy)

  1. The effects produced on man by subcutaneous injections of a liquid obtained from the testicles of animals (1889)

Spermin-Poehl (Sperminum-Poehl) organotherapy

  1. Rational organotherapy: with reference to urosemiology (1906)

Marine plasma (Sérum de Quinton)

  1. Isotonic Sea Water in Therapeutics (1913)

Voronoff testicular xenograft (chimpanzee-to-human)

  1. Voronoff to virion: 1920s testis transplantation and AIDS (2012)

Cellular therapy (Frischzellentherapie)

  1. Introduction to Cellular Therapy (1960)

Antireticular cytotoxic serum (ACS / ATsS)

  1. The Life and Death of a Soviet-Era Search for Longevity (2024)

Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG)

  1. Multi-omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange (2025)
current continuity: Multi-omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange, Can This Trendy Anti-Aging Treatment Really Help You Live Longer?
FRAMING SOURCES
  1. Injection, ligation and transplantation: the search for the glandular fountain of youth (2007)
  2. The Life and Death of a Soviet-Era Search for Longevity (2024)
  3. Multi-omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange (2025)