METHUSELAH ARCHIVE LINEAGE / GLAND-AND-HORMONE
Lineage

Gland and hormone rejuvenation

Restore youth by manipulating the reproductive or endocrine organs believed to govern vitality.
span:1889–1942
cases:5
status:historical
THE THREAD
1889–1894 Brown-Séquard testicular extract (organotherapy) brown-sequard-self-injection-1889 1893–1908 Spermin-Poehl (Sperminum-Poehl) organotherapy poehl-spermine-1893-1908 1917–1942 Brinkley goat-gland transplantation (goat-to-human gonad implant) brinkley-goat-gland-1917-1942 1920–1939 Steinach Vasoligation (Steinach Operation) steinach-vasectomy-rejuvenation-1920-1939 1920–1935 Voronoff testicular xenograft (chimpanzee-to-human) voronoff-graft-1920-1935
THROUGH-LINE

Extract injection, ligation, grafting, and gland transplantation repeatedly turned emerging endocrine ideas into elite rejuvenation procedures without controlled evidence establishing benefit.

Restore youth by manipulating the reproductive or endocrine organs believed to govern vitality. The member timeline and evidence ledgers below show where the comparison is documented and where present continuity is established. Historical outcomes frame the recurring question; they do not determine the evidence verdict for a current member.

CASES IN THIS LINEAGE
  1. Brown-Séquard testicular extract (organotherapy) (1889–1894)
  2. Spermin-Poehl (Sperminum-Poehl) organotherapy (1893–1908)
  3. Brinkley goat-gland transplantation (goat-to-human gonad implant) (1917–1942)
  4. Steinach Vasoligation (Steinach Operation) (1920–1939)
  5. Voronoff testicular xenograft (chimpanzee-to-human) (1920–1935)
EDGE EVIDENCE

Brown-Séquard testicular extract (organotherapy)

  1. The effects produced on man by subcutaneous injections of a liquid obtained from the testicles of animals (1889)

Spermin-Poehl (Sperminum-Poehl) organotherapy

  1. Rational organotherapy: with reference to urosemiology (1906)

Brinkley goat-gland transplantation (goat-to-human gonad implant)

  1. Injection, ligation and transplantation: the search for the glandular fountain of youth (2007)

Steinach Vasoligation (Steinach Operation)

  1. Rejuvenation in the early 20th century (1997)

Voronoff testicular xenograft (chimpanzee-to-human)

  1. Voronoff to virion: 1920s testis transplantation and AIDS (2012)
FRAMING SOURCES
  1. Injection, ligation and transplantation: the search for the glandular fountain of youth (2007)
  2. Voronoff to virion: 1920s testis transplantation and AIDS (2012)
  3. Rejuvenation in the early 20th century (1997)