METHUSELAH ARCHIVE LINEAGE / LABORATORY-SIGNS-OF-REJUVENATION
Lineage

Laboratory signs of rejuvenation

A historical comparison of rejuvenation claims supported through cell behavior, animal results, biomarkers, or biological-age measurements.
span:1912–present
cases:5
status:live terminus
terminus:Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG)
THE THREAD
1912–1946 Immortal Cell Culture (Carrel's Chick-Heart Experiment) carrel-immortal-cells-1912-1946 1951–1988 Gerovital H3 (procaine anti-aging therapy) CONTINUING aslan-gerovital-1951-1988 2003–present Sirtuin-activating compounds (resveratrol, then NMN) CONTINUING sinclair-resveratrol-nmn-2003-present 2021–present Blueprint (Project Blueprint) CONTINUING johnson-blueprint-2021-present 2024–present Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG) LIVE TERMINUS tpe-ivig-2024-present
THROUGH-LINE

Historical members used laboratory or surrogate signals to support broader rejuvenation claims. Any present member's operation and evidence status remain confined to that member's Case and sources.

The historical record includes rejuvenation claims supported through cell behavior, animal results, and laboratory measurements. This page groups source-backed comparison edges for navigation. Any present member’s operation and evidence status are stated only in that member’s Case and attached sources; historical outcomes do not transfer.

CASES IN THIS LINEAGE
  1. Immortal Cell Culture (Carrel's Chick-Heart Experiment) (1912–1946)
  2. Gerovital H3 (procaine anti-aging therapy) (1951–1988) · CONTINUING
  3. Sirtuin-activating compounds (resveratrol, then NMN) (2003–present) · CONTINUING
  4. Blueprint (Project Blueprint) (2021–present) · CONTINUING
  5. Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG) (2024–present) · LIVE TERMINUS
EDGE EVIDENCE

Immortal Cell Culture (Carrel's Chick-Heart Experiment)

  1. Dr. Carrel's immortal cells (1980)

Gerovital H3 (procaine anti-aging therapy)

  1. Long-term treatment with procaine (Gerovital H3) in albino rats (1965)
  2. The systemic use of procaine in the treatment of the elderly: a review (1977)
current continuity: Gerovital H3 5 ml ampoules, Gerovital H3 national medicines-register entry, KH-3

Sirtuin-activating compounds (resveratrol, then NMN)

  1. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (2003)
current continuity: Metro International Biotech, Can supplements containing NMN, NAD+ and resveratrol really slow ageing? Here's what the evidence says

Blueprint (Project Blueprint)

  1. Bryan Johnson's Protocol (2026)
  2. From population science to the clinic? Limits of epigenetic clocks as personal biomarkers (2025)
current continuity: Bryan Johnson's Protocol, From population science to the clinic? Limits of epigenetic clocks as personal biomarkers

Therapeutic plasma exchange with intravenous immunoglobulin (TPE-IVIG)

  1. Multi-omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange (2025)
current continuity: Multi-omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange, Can This Trendy Anti-Aging Treatment Really Help You Live Longer?
FRAMING SOURCES
  1. Dr. Carrel's immortal cells (1980)
  2. The systemic use of procaine in the treatment of the elderly: a review (1977)
  3. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (2003)
  4. From population science to the clinic? Limits of epigenetic clocks as personal biomarkers (2025)
  5. Multi-omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange (2025)