The mechanism claim is the surrogate construct underneath the rejuvenation promise: spermin framed as an oxidation catalyst and antitoxin against autointoxication, argued in Poehl’s 1894 monograph on spermin and metabolism and elaborated in the 1898 spermine-theory book. It was never demonstrated as an oxidative or antitoxic effect in patients; it rested on the autointoxication doctrine and on clinical impression. The claim is refuted as a mechanism: spermine’s actual cellular role is nucleic-acid binding and growth modulation (Lightfoot and Hall 2014), not catalysis of tissue oxidation, and the autointoxication framework it depended on was abandoned. Poehl’s specific doctrine was rejected (Mann 1954), though Mann notes spermine as a polyamine is not pharmacologically inert.