Endogenous polyamine function: the RNA perspective
secondary literature · 2014
LINK
SUMMARY
A 2014 Nucleic Acids Research review of the cellular functions of the polyamines (putrescine, spermidine, spermine), centered on their interactions with RNA and other nucleic acids. Used in this case to document what spermine is actually known to do in the cell: bind and stabilize nucleic acids and modulate translation, a role unrelated to Poehl's claimed oxidation-catalyst and antitoxin action. Identifiers confirmed deterministically against PubMed/NCBI (PMID 25232095; DOI 10.1093/nar/gku837; PMCID PMC4191411); authors, journal, volume, issue, pages, and year copied from the NCBI E-utilities record.
NOTES
Lightfoot and Hall (2014) describes spermine in its modern biochemical role as one of the cellular polyamines that bind nucleic acids and influence gene expression and translation. It is cited here to make concrete the gap between the real molecule and Poehl’s doctrine: the substance is genuine and biologically active, but its actual activity has nothing to do with restoring vital energy or reversing senile decline.