This is the narrow, real kernel inside Grahamism, set out at length in Graham’s 1837 A Treatise on Bread, and Bread-Making, which argued for coarsely ground, home-baked whole-wheat bread over the commercially milled and bolted white bread of contemporary bakeries. It is classified with a surrogate endpoint: whole-grain share of the diet is a measurable dietary exposure, not itself a hard mortality outcome. It is recorded as replicated because a modern systematic review and dose-response meta-analysis of prospective cohort studies found that higher whole-grain consumption is associated with reduced risk of cardiovascular disease, cancer, and all-cause mortality (Aune et al., BMJ 2016;353:i2716, PMID 27301975). The replication is narrow and matters for its limits: it supports whole grain over refined flour as a dietary exposure correlated with better population-level outcomes in twentieth- and twenty-first-century cohorts; it says nothing about, and does not rehabilitate, Graham’s own theory of nervous excitability, his masturbation-insanity claim, or his broader promise of near-immunity from disease.