The founding claim of the entire case. The yeast lifespan-extension result itself (Howitz et al., Nature, 2003) was a real, published finding in a model organism, but the proposed mechanism — that resveratrol directly binds and activates SIRT1 — was shown seven years later to be an artifact of the fluorescent reporter group used in the original biochemical assay (Pacholec et al., Journal of Biological Chemistry, 2010): resveratrol did not activate SIRT1 against native, unlabeled substrates. The archive marks this claim refuted at the mechanistic level on which its commercial and popular life-extension narrative was built, independent of whatever descriptive effect resveratrol produced in the original yeast experiment.