The proposed mechanism behind the internal tonic, as Memorial Sloan Kettering’s current About Herbs monograph records Hoxsey’s own description: that it “stimulates the elimination of toxins that poison the system, thereby correcting the abnormal blood chemistry and normalizing cell metabolism.” No specific toxin, metabolic pathway, or blood-chemistry abnormality was ever identified or measured; the claim names no testable target. Memorial Sloan Kettering’s monograph states plainly that none of this is “substantiated by scientific data.”