Metabolic effects of HAY's diet
The Wutzke et al. 2001 study in Isotopes in Environmental and Health Studies is a controlled metabolic comparison of the Hay food-combining diet against an energy-matched conventional mixed diet. Measuring substrate oxidation by stable-isotope tracer and assessing body composition, it found no advantage for food separation: body weight and body composition were effectively the same under the Hay diet as under the mixed control. It is cited here for one bounded point in the disconfirmation, that the act of separating concentrated starches from concentrated proteins yields no measurable metabolic or body-composition benefit when calories are held equal. It is a small modern metabolic study and is not evidence about lifespan; the case does not present it as such. Identifiers were confirmed on PubMed (PMID 11924853) and the DOI resolver (10.1080/10256010108033298).