Uric Acid Nephrolithiasis: A Systemic Metabolic Disorder

Modern peer-reviewed clinical review (PMID confirmed by direct fetch of the PubMed record; full text also confirmed present by direct interactive fetch, stating that alkali therapy can dissolve existing pure uric-acid stones but not calcium-containing stones). Stated here by paraphrase rather than verbatim quotation because a mechanical re-check found the PMC page intermittently serves a reCAPTCHA challenge page to unauthenticated automated fetches (confirmed directly across repeated attempts), which would make a literal verify-quotes block unreliable. Used in this bundle as the modern clinical-science confirmation of the general mechanism a 2013 professional urological assessment (baus-goddard-joanna-stephens-2013) attributes specifically to the alkaline-soap ingredient in Stephens's recipe: an alkali, dosed as modern therapy, can dissolve uric-acid/urate stones, but has no dissolving action on calcium-oxalate and other calcium-bearing stones that make up most cases. This source establishes the modern pharmacological principle only; it does not itself assess Stephens's 18th-century recipe or dosing, and no source in this bundle documents that her specific undosed preparation achieved therapeutic urinary alkalinization in any recorded patient.