ClinicalTrials.gov registration NCT06534450

Pre-registration of the central clinical trial that subsequently produced the *Aging Cell* publication (Fuentealba et al, 2025). The registration documents the pre-specified primary and secondary endpoints, study design (single-blind, randomized, placebo-controlled, four-arm), sample size target, and analysis plan. Pre-registration is a methodological strength that constrains post-hoc analytical flexibility and allows verification that the reported analyses were planned rather than data-driven. The registration ID NCT06534450 should be the starting point for any independent assessment of the trial's pre-specified vs. published endpoints.