Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

clinical paper · 2018

type:clinical paper

year:2018

citation:Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173(1):74-89.e20. DOI: 10.1016/j.cell.2018.02.008. PMID: 29570999.

LINK

https://pubmed.ncbi.nlm.nih.gov/29570999/

SUMMARY

Harvard Medical School study (senior author David Sinclair) reporting that the NAD+ precursor NMN restores capillary density and exercise endurance in aged mice via SIRT1-dependent angiogenic signaling in endothelial cells. PMID and DOI both resolved directly (PubMed record includes an unrelated figure-panel erratum, PMID 30735637, not material to the findings cited here). Peer-reviewed animal study; the founding paper of the case's current NMN/NAD+ commercial phase.

NOTES

The mouse study that reoriented Sinclair’s public longevity advocacy from resveratrol to NMN after the Sirtris/resveratrol story collapsed. A real, peer-reviewed animal finding, cited in the case as a surrogate result (mouse capillary density and treadmill endurance) rather than evidence of a human lifespan benefit.