Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research
secondary literature · 2018
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SUMMARY
A 2018 Journal of Biological Chemistry minireview introduction surveying the modern history of polyamine research, including the 1920s isolation and characterization of the spermine free base by Dudley and Rosenheim. Establishes spermine as a defined aliphatic polyamine integral to cell metabolism, against which Poehl's pre-structural 'spermin' concept can be measured. Identifiers confirmed deterministically against PubMed/NCBI (PMID 30377254; DOI 10.1074/jbc.TM118.006291; PMCID PMC6290159); authors, journal, volume, issue, pages, and year copied from the NCBI E-utilities record.
NOTES
Pegg’s 2018 minireview anchors the modern biochemical understanding of spermine: a well-characterized polyamine whose free base and structure were established in the 1920s (Dudley and Rosenheim), with a defined biosynthetic pathway and cellular roles. It is cited in this case for the historical fact that spermine’s true chemical identity was settled only after Poehl’s death, and that the settled identity bears no relation to his quasi-vital oxidation-catalyst doctrine.