METHUSELAH ARCHIVE SOURCES / LIJESEN-HCG-OBESITY-METAANALYSIS-1995

The effect of human chorionic gonadotropin (hCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis

clinical paper · 1995
type:clinical paper
year:1995
citation:Lijesen GK, Theeuwen I, Assendelft WJ, Van Der Wal G. "The effect of human chorionic gonadotropin (hCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis." British Journal of Clinical Pharmacology. 1995;40(3):237-243. PMID: 8527285. PMCID: PMC1365103. doi:10.1111/j.1365-2125.1995.tb05779.x.
LINK
https://www.ncbi.nlm.nih.gov/books/NBK66355/
SUMMARY
NCBI Bookshelf record, Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews, fetched directly (2026-07-10). Reproduces the paper's bibliographic details (Lijesen GK, Theeuwen I, Assendelft WJ, Van Der Wal G; British Journal of Clinical Pharmacology 1995; 40(3): 237-243; PMC1365103; PubMed 8527285) and its own "Authors' conclusions" summary of the meta-analysis: "There is no scientific evidence that hCG causes weight-loss, redistributes fat, staves off hunger or induces a feeling of well-being. Therefore, the use of hCG should be regarded as an inappropriate therapy for weight reduction." (Direct fetches of pubmed.ncbi.nlm.nih.gov and pmc.ncbi.nlm.nih.gov for the same record returned inconsistent, much shorter page content later in this run, an apparent rate-limit/bot-mitigation response; this NCBI Bookshelf DARE page fetched reliably and is used as the primary quoted source instead.)
NOTES

The peer-reviewed clinical-literature source establishing that hCG injections add no weight-loss benefit beyond the caloric restriction of the diet itself, cited by the natural-cures-program intervention and the trudeau-weightloss-hcg-claim claim so that this general medical-evidence statement rests on a controlled-trial meta-analysis rather than only on the FTC/DOJ enforcement record (which establishes that Trudeau’s specific marketing claims were false and deceptive, not, on its own, the underlying clinical-trial evidence on hCG). This NCBI Bookshelf DARE record’s own conclusion: “There is no scientific evidence that hCG causes weight-loss, redistributes fat, staves off hunger or induces a feeling of well-being.”