METHUSELAH ARCHIVE SOURCES / HORNER-DNP-CATARACT-ARCHOPHT-1942

Dinitrophenol and Its Relation to Formation of Cataract

clinical paper · 1942
type:clinical paper
year:1942
citation:Warren D. Horner, Dinitrophenol and Its Relation to Formation of Cataract, Archives of Ophthalmology 27(6) (1942): 1097-1121. doi:10.1001/archopht.1942.00880060073002
SUMMARY
Contemporaneous ophthalmological case series documenting bilateral cataracts, in some cases progressing to near-blindness, among individuals who had taken DNP-containing diet pills in the 1930s; among the primary clinical sources establishing the ocular toxicity that, together with hyperthermic deaths, led to the drug's removal from the market.
NOTES

Contemporaneous (1942) peer-reviewed ophthalmological case series documenting the cataract epidemic among 1930s DNP dieters; the direct professional analysis of the marketed effects required for a historical intervention’s evidentiary-failure record.