METHUSELAH ARCHIVE SOURCES / GRUNDLINGH-DNP-WEIGHT-LOSS-TOXICITY-2011

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

clinical paper · 2011
type:clinical paper
year:2011
citation:Johann Grundlingh, Paul I. Dargan, Marwa El-Zanfaly, and David M. Wood, '2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death,' Journal of Medical Toxicology 7(3) (2011): 205-212. PMID 21739343. doi:10.1007/s13181-011-0162-6
SUMMARY
Comprehensive modern toxicological review tracing DNP's history from 1930s marketing through its post-2000 internet-driven resurgence as a bodybuilding and slimming aid; records very few reported deaths from the late 1930s until the 2000s, and counts 62 published deaths attributed to DNP in the medical literature, followed by a marked recent increase in deaths tied to online availability; states there is no specific antidote for DNP poisoning; as of its 2011 publication, a primary authority establishing that the post-2000 online market is a direct continuation of the same substance and marketing claim first disconfirmed in 1938.
NOTES

Comprehensive peer-reviewed clinical toxicology review establishing the causal and historical continuity between the 1930s DNP episode and its modern online resurgence, and documenting the absence of a safe dose or antidote.