Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

clinical paper · 2013

type:clinical paper

year:2013

citation:Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell. 2013;155(7):1624-1638. DOI: 10.1016/j.cell.2013.11.037. PMID: 24360282.

LINK

https://pubmed.ncbi.nlm.nih.gov/24360282/

SUMMARY

Harvard Medical School study (senior author David Sinclair) reporting that raising NAD+ levels with the precursor NMN restores mitochondrial function in old mice to that of a young mouse in a SIRT1-dependent manner. PMID and DOI both resolved directly on PubMed/Crossref; title and full author list match. This is the paper establishing NMN's entry into Sinclair's longevity research (December 2013), preceding the 2018 Cell vascular-aging paper the case also cites.

NOTES

Founding paper for the NMN/NAD+ phase of the case, cited to support the ingredient entity’s first_introduced.year: 2013 and the intervention’s account of how Sinclair’s public advocacy moved from resveratrol to NAD+ boosters after the Sirtris story collapsed.