METHUSELAH ARCHIVE SOURCES / CAMERON-PAULING-PNAS-1978-REEVALUATION

Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer

clinical paper · 1978
type:clinical paper
year:1978
citation:Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1978;75(9):4538-4542. PMID: 279931.
LINK
https://pubmed.ncbi.nlm.nih.gov/279931/
SUMMARY
Follow-up to the 1976 PNAS paper, reporting that 22% of the ascorbate-treated terminal cancer patients survived more than one year, versus 0.4% of a second, separate set of 1,000 retrospective control patients (per frederick-cancer-gov-iv-vitamin-c-2020's summary of this paper). Same non-randomized, unblinded, retrospective-control design as the 1976 paper. PMID resolved directly on PubMed; title, authors, journal, volume/issue/pages all match.
NOTES

The second Cameron-Pauling PNAS paper, repeating the retrospective-control design of the 1976 study with a larger apparent effect size, and equally unable to withstand the randomized, controlled tests that followed at the Mayo Clinic.